As the molecular basis of Duchenne Muscular Dystrophy (DMD) was being discovered, increasing focus was placed on the mechanisms of progressive failure of myoregeneration. In this study, we propose a pathogenesis model for DMD, where an autocrine growth factor release of TGF-b1—from necrotic myofibers—could contribute to the increasing loss of muscle regeneration. In fact, we report evidence that DMD myoblasts reduce their proliferation rate, in time and later cultures; in connection with this, we observed TGF-b1 increase in conditioned media of DMD myoblasts, able to control the myoblast growth by reducing fusion and differentiation of DMD satellite cells.
|Titolo:||Defective growth in vitro of Duchenne Muscular Dystrophy myoblasts: the molecular and biochemical basis|
MELONE, Mariarosa Anna Beatrice (Corresponding)
|Data di pubblicazione:||1999|
|Appare nelle tipologie:||1.1 Articolo in rivista|