A new and versatile on-line automated solid-phase approach to obtain cyclic PNA (I and III) and cyclic PNA-DNA chimeras (II) in highly pure form has been developed. Starting from a Tentagel matrix functionalized with a 3-chloro-4-hydroxyphenylacetic linker, the synthesis of representative, new cyclic molecules by standard peptide and phosphoramidite-based chemistry has been achieved. © 2006 American Chemical Society.
Titolo: | Solid-phase synthesis of cyclic PNA and PNA-DNA chimeras |
Autori: | |
Data di pubblicazione: | 2006 |
Rivista: | |
Abstract: | A new and versatile on-line automated solid-phase approach to obtain cyclic PNA (I and III) and cyclic PNA-DNA chimeras (II) in highly pure form has been developed. Starting from a Tentagel matrix functionalized with a 3-chloro-4-hydroxyphenylacetic linker, the synthesis of representative, new cyclic molecules by standard peptide and phosphoramidite-based chemistry has been achieved. © 2006 American Chemical Society. |
Handle: | http://hdl.handle.net/11591/190019 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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