Objective: We aimed to evaluate the feasibility and short-term efficacy of endobronchial treatment with one-way valves for giant emphysematous bulla in surgically unfit patients. Methods: Nine consecutive patients with giant emphysematous bulla were enrolled in the last 3 years. Endobronchial valves were placed in the segmental bronchi to functionally isolate the airway that supplied the bulla, favouring the deflation of the bulla and its atelectasis. Mean value +/- standard deviation of forced expiratory volume in 1 s (FEV1), preoperative forced vital capacity (FVC) and residual volume (RV) were: 1.0 + 0.2 l (35 + 9.9%), 1.5 + 0.5 l (42 + 12%) and 5.5 + 0.7 l (231 + 32%), respectively; and the values for diffusion capacity for carbon monoxide was 31 +/- 4.6% and for the 6-min walk test (6MWT) was 156 +/- 92 m); all patients required supplemental oxygen at rest. The St. George's Respiratory Questionnaire (SGRQ) score was 85 +/- 4.6. Results: At 24-48 h after the procedure, the mean value of FEV1 (from 35% to 47%, p < 0.01), FVC (from 42% to 52%, p < 0.01), diffusion lung capacity for carbon monoxide (DLCO) (from 31% to 33%, p < 0.05) and 6MWT (from 156 m to 281 m, p < 0.01) significantly improved with respect to baseline value. Conversely, mean value of total lung capacity (TLC) (from 157% to 123%, p < 0.01) RV (from 231% to 158%, p < 0.01) and SGRQ score (from 85 to 37, p < 0.01) was significantly lower than baseline data; these changes were preserved during the entire follow-up. Conclusion: Our preliminary data confirm the feasibility and the potential efficacy of this strategy with significantly immediate improvement of respiration and quality of life, which remains stable during 6 months of follow-up. (C) 2011 European Association for Cardio-Thoracic Surgery. Published by Elsevier B. V. All rights reserved.

Endobronchial treatment of giant emphysematous bullae with one-way valves: a new approach for surgically unfit patients.

SANTINI, Mario;FIORELLI, Alfonso;VICIDOMINI, Giovanni;
2011

Abstract

Objective: We aimed to evaluate the feasibility and short-term efficacy of endobronchial treatment with one-way valves for giant emphysematous bulla in surgically unfit patients. Methods: Nine consecutive patients with giant emphysematous bulla were enrolled in the last 3 years. Endobronchial valves were placed in the segmental bronchi to functionally isolate the airway that supplied the bulla, favouring the deflation of the bulla and its atelectasis. Mean value +/- standard deviation of forced expiratory volume in 1 s (FEV1), preoperative forced vital capacity (FVC) and residual volume (RV) were: 1.0 + 0.2 l (35 + 9.9%), 1.5 + 0.5 l (42 + 12%) and 5.5 + 0.7 l (231 + 32%), respectively; and the values for diffusion capacity for carbon monoxide was 31 +/- 4.6% and for the 6-min walk test (6MWT) was 156 +/- 92 m); all patients required supplemental oxygen at rest. The St. George's Respiratory Questionnaire (SGRQ) score was 85 +/- 4.6. Results: At 24-48 h after the procedure, the mean value of FEV1 (from 35% to 47%, p < 0.01), FVC (from 42% to 52%, p < 0.01), diffusion lung capacity for carbon monoxide (DLCO) (from 31% to 33%, p < 0.05) and 6MWT (from 156 m to 281 m, p < 0.01) significantly improved with respect to baseline value. Conversely, mean value of total lung capacity (TLC) (from 157% to 123%, p < 0.01) RV (from 231% to 158%, p < 0.01) and SGRQ score (from 85 to 37, p < 0.01) was significantly lower than baseline data; these changes were preserved during the entire follow-up. Conclusion: Our preliminary data confirm the feasibility and the potential efficacy of this strategy with significantly immediate improvement of respiration and quality of life, which remains stable during 6 months of follow-up. (C) 2011 European Association for Cardio-Thoracic Surgery. Published by Elsevier B. V. All rights reserved.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11591/189952
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