Tumors arise from single cells that develop into large populations sharing a series of genetic alterations. The single phenotypic feature that best characterizes a transformed cell is its ability to proliferate indefinitely when left undisturbed.1 The recognition of specific genes that modulate proliferation, has led to studies on the cell cycle.2 Homeostasis has a great importance in the development of tumors and is regulated by a balance among proliferation, the arrest of growth and programmed death (apoptosis).
Regulation of p53 function in normal and malignant cells
BONTEMPO, Paola;ARMETTA, Ignazio;ABBONDANZA, Ciro;SCHIAVONE, Ettore Mariano;NOLA, Ernesto;PUCA, Giovanni Alfredo;MOLINARI, Anna Maria
1999
Abstract
Tumors arise from single cells that develop into large populations sharing a series of genetic alterations. The single phenotypic feature that best characterizes a transformed cell is its ability to proliferate indefinitely when left undisturbed.1 The recognition of specific genes that modulate proliferation, has led to studies on the cell cycle.2 Homeostasis has a great importance in the development of tumors and is regulated by a balance among proliferation, the arrest of growth and programmed death (apoptosis).File in questo prodotto:
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