The onset and course of pemphigus depend on the interaction between predisposing and inducing factors. Genetic predisposition is known to be associated with human leukocyte antigens (HLAs), in particular with DR4, 14 and DQ1. Long-term treatment with systemic IFN-α often induces the appearance of pemphigus antibodies in nonpemphigus patients.4 Repeated administration of imiquimod, whilst altering the local immune response, may cause acantholytic lesions as a result of the production of IFN-α, a cytokine commonly identified as a pemphigus-inducing drug.

Contact pemphigus: a side-effect of imiquimod therapy.

LO SCHIAVO, Ada;RUOCCO, Eleonora;
2008

Abstract

The onset and course of pemphigus depend on the interaction between predisposing and inducing factors. Genetic predisposition is known to be associated with human leukocyte antigens (HLAs), in particular with DR4, 14 and DQ1. Long-term treatment with systemic IFN-α often induces the appearance of pemphigus antibodies in nonpemphigus patients.4 Repeated administration of imiquimod, whilst altering the local immune response, may cause acantholytic lesions as a result of the production of IFN-α, a cytokine commonly identified as a pemphigus-inducing drug.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11591/189238
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