Background. Acute viral hepatitis due to hepatitis A virus is a self-limited illness that infrequently has a severe clinical course. Methods. We analyzed the virological characteristics of acute hepatitis A in a patient with a severe clinical presentation (peak total and conjugated bilirubin levels, 65.5 mg/dL and 40.1 mg/dL, respectively) and a course of disease that lasted 7 months. Results. Hepatitis A virus sequencing revealed coinfection with 2 subgenotypes of hepatitis A virus (Ia and Ib) as etiological factors of the illness. Conclusions. Hepatitis A virus Ia and Ib coinfection may have accounted for the prolonged and severe course of illness.
Acute hepatitis with severe cholestasis and prolonged clinical course due to hepatitis A virus Ia and Ib coinfection
COPPOLA, Nicola;PISATURO M.;PASQUALE, Giuseppe;SAGNELLI, Caterina;
2007
Abstract
Background. Acute viral hepatitis due to hepatitis A virus is a self-limited illness that infrequently has a severe clinical course. Methods. We analyzed the virological characteristics of acute hepatitis A in a patient with a severe clinical presentation (peak total and conjugated bilirubin levels, 65.5 mg/dL and 40.1 mg/dL, respectively) and a course of disease that lasted 7 months. Results. Hepatitis A virus sequencing revealed coinfection with 2 subgenotypes of hepatitis A virus (Ia and Ib) as etiological factors of the illness. Conclusions. Hepatitis A virus Ia and Ib coinfection may have accounted for the prolonged and severe course of illness.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
