Tight glycemic control reduces heart inflammation and remodeling during acute myocardial infarction in hyperglycemic patients.

Objectives. We analyzed the molecular mechanisms evoked by tight glycemic control during post-infarction remodeling in human hearts. Background. The molecular mechanisms by which tight glycemic control improves heart remodeling during acute myocardial infarction (AMI) are still largely unknown. Methods. Eighty-eight patients with first AMI undergoing coronary bypass surgery were studied: 38 normoglycemic patients served as the control group; hyperglycemic patients (glucose =140 mg/dl) were randomized to intensive glycemic control (IGC) (n = 25; glucose 80 to 140 mg/dl) or conventional glycemic control (CGC) (n = 25; glucose 180 to 200 mg/dl) for almost 3 days before surgery, with insulin infusion followed by subcutaneous insulin treatment. Echocardiographic parameters were investigated at admission and after treatment period. During surgery, oxidative stress (nitrotyrosine, superoxide anion [O2 –] production, inducible nitric oxide synthase [iNOS]),inflammation (nuclear factor kappa B [NF_B], tumor necrosis factor [TNF]-a, and apoptosis (caspase-3) were analyzed in biopsy specimens taken from the peri-infarcted area. Results. Compared with normoglycemic patients, hyperglycemic patients had higher myocardial performance index (MPI) (p < 0.05), reduced ejection fraction (p 0.05), more nitrotyrosine, iNOS, and O2 _ production, more macrophages, T-lymphocytes, and HLA-DR (Dako, Milan, Italy) cells, and more NF_B-activity, TNF-a, and caspase-3 levels (p < 0.01) in peri-infarcted specimens. After the treatment period, plasma glucose reduction was greater in the IGC than in the CGC group (p < 0.001). Compared with IGC patients, CGC patients had higher MPI (p _0.02), had lower ejection fraction (p < 0.05), and had more markers of oxidative stress, more inflammation and apoptosis (p < 0.01) in peri-infarcted specimens. Conclusions. Tight glycemic control, by reducing oxidative stress and inflammation, might reduce apoptosis in peri-infarcted areas and remodeling in AMI patients.