High levels of homocysteine have been implicated as a cardiovascular risk factor in the general population and in patients with chronic renal failure, and particularly patients on hemodialysis. To classify a risk factor as causally related to a certain disease, both strong epidemiologic data and sound basic-science studies establishing a mechanism are needed. Among the latter, the hypomethylation of proteins and DNA, and protein homocysteinylation, have been investigated in uremia, providing for an array of toxic effects in this disease. © 2008 National Kidney Foundation, Inc.
Titolo: | Is Homocysteine Toxic in Uremia? | |
Autori: | ||
Data di pubblicazione: | 2008 | |
Rivista: | ||
Handle: | http://hdl.handle.net/11591/186597 | |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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