Peripheral arterial disease (PAD) is a common circulatory problem. In 2010 almost 18 million U.S. citizens suffered from PAD. Reflecting the aging population this number is projected to increase to 21 million by 2020. Critical limb ischemia (CLI), the most severe and deadly form of the disease, currently afflicts 2.8 to 3.5 million of those with PAD. By 2020, the U.S.prevalence of CLI is forecast to grow to between 3.6 and 4.5 million. Among PAD patients,about 1-3% will develop CLI .
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