The solid-phase synthesis of 3'-derivatized oligonucleotides, by using a support which links the first nucleoside-3'-phosphate through the nucleobase, is reported. Following this procedure, the marking molecules can easily incorporated in satisfactory yields at the 3'-phosphate terminus either before or after the chain assembly.
New solid-phase approach to obtain 3'-derivatized oligonucleotides
MESSERE, Anna;
1996
Abstract
The solid-phase synthesis of 3'-derivatized oligonucleotides, by using a support which links the first nucleoside-3'-phosphate through the nucleobase, is reported. Following this procedure, the marking molecules can easily incorporated in satisfactory yields at the 3'-phosphate terminus either before or after the chain assembly.File in questo prodotto:
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