The solid-phase synthesis of 3'-derivatized oligonucleotides, by using a support which links the first nucleoside-3'-phosphate through the nucleobase, is reported. Following this procedure, the marking molecules can easily incorporated in satisfactory yields at the 3'-phosphate terminus either before or after the chain assembly.
Titolo: | New solid-phase approach to obtain 3'-derivatized oligonucleotides | |
Autori: | ||
Data di pubblicazione: | 1996 | |
Rivista: | ||
Abstract: | The solid-phase synthesis of 3'-derivatized oligonucleotides, by using a support which links the first nucleoside-3'-phosphate through the nucleobase, is reported. Following this procedure, the marking molecules can easily incorporated in satisfactory yields at the 3'-phosphate terminus either before or after the chain assembly. | |
Handle: | http://hdl.handle.net/11591/186349 | |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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