21, 31-dideoxy- and 2 13 ‘-dideoxy-21, 3 2-didehydrocy- tidine (d2C and d4C) have been synthesized in good yields from 21-deoxyuridine via dichlorinated derivatives 7ab. The same synthetic strategy was used in the synthesis of d2CMeand d4CMefrom thymidine. Following this method the evaluable 3*-chloro-21-deoxycytidine derivatives 9–12 can easily be obtained. © 1993, Taylor & Francis Group, LLC. All rights reserved.
Improved synthesis of 2-, 3- -dideoxycytidine (d2c) and its correlated nucleoside analogues
MESSERE, Anna;
1993
Abstract
21, 31-dideoxy- and 2 13 ‘-dideoxy-21, 3 2-didehydrocy- tidine (d2C and d4C) have been synthesized in good yields from 21-deoxyuridine via dichlorinated derivatives 7ab. The same synthetic strategy was used in the synthesis of d2CMeand d4CMefrom thymidine. Following this method the evaluable 3*-chloro-21-deoxycytidine derivatives 9–12 can easily be obtained. © 1993, Taylor & Francis Group, LLC. All rights reserved.File in questo prodotto:
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