The manuscript describes the molecular mechanism by which members of the family of nuclear receptors prevent the potential damage to DNA during transcription of target genes elicited by the use of ROS to shape chromatin. The mechanism is based on the presence of phosphorylated serine 10 in histone H3 to prevent unbalanced DNA oxidation waves. The opportunities raised by the use of voluntary derangement of this servo system to induce selective death in hormone-responsive transformed cells are also discussed.
Nuclear receptor-induced transcription is driven by spatially and timely restricted waves of ROS: the role of Akt, IKKα and DNA damage repair enzymes.
CASTORIA, Gabriella;MIGLIACCIO, Antimo
2014
Abstract
The manuscript describes the molecular mechanism by which members of the family of nuclear receptors prevent the potential damage to DNA during transcription of target genes elicited by the use of ROS to shape chromatin. The mechanism is based on the presence of phosphorylated serine 10 in histone H3 to prevent unbalanced DNA oxidation waves. The opportunities raised by the use of voluntary derangement of this servo system to induce selective death in hormone-responsive transformed cells are also discussed.File in questo prodotto:
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