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EnglishNon-thyroid neoplasis were analysed by Southern blot of genomic DNA and DNA prepared by reverse transcription and amplification by polymerase chain reaction (RT/PCR) for the activation of the RET oncogene. It is known that the rearrangement of RET occurs in about 10%-20% of human thyroid papillary carcinomas. None of 528 non-thyroid tumours showed rearrangement of the RET proto-oncogene, whereas three out of 30 thyroid papillary carcinomas were positive for RET activation. Therefore the activation of RET seems to be a somatic cell mutation specific to human thyroid carcinomas.
| Titolo: | INVOLVEMENT OF RET ONCOGENE IN HUMAN TUMORS - SPECIFICITY OF RET ACTIVATION TO THYROID-TUMORS |
| Autori: | |
| Data di pubblicazione: | 1993 |
| Rivista: | |
| Abstract: | Non-thyroid neoplasis were analysed by Southern blot of genomic DNA and DNA prepared by reverse transcription and amplification by polymerase chain reaction (RT/PCR) for the activation of the RET oncogene. It is known that the rearrangement of RET occurs in about 10%-20% of human thyroid papillary carcinomas. None of 528 non-thyroid tumours showed rearrangement of the RET proto-oncogene, whereas three out of 30 thyroid papillary carcinomas were positive for RET activation. Therefore the activation of RET seems to be a somatic cell mutation specific to human thyroid carcinomas. |
| Handle: | http://hdl.handle.net/11591/183747 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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