The case of a patient with an extranodal non-Hodgkin lymphoma and three M-components (IgGκ + IgGλ + IgMλ.) in the serum is described. Three separate populations of M-component producing cells have been identified. Since a κ→λ chain switch is not demonstrated, the synthesis of IgGκ and IgGλ by two distinct clones is obvious. IgMλ and IgGλ. M-components are synthesized by two different plasma cell populations that could represent two unrelated cell clones or, alternatively, two subclones originated by a common precursor. After chemotherapy the IgGλ M-component is replaced by heavy γ chains without evidence of λ light chains. © 2003 Wiley-Liss, Inc.
Triclonal gammopathy in an extranodal non-Hodgkin lymphoma patient
TIRELLI, Armando;GUASTAFIERRO, Salvatore;LUCIVERO, Giacomo
2003
Abstract
The case of a patient with an extranodal non-Hodgkin lymphoma and three M-components (IgGκ + IgGλ + IgMλ.) in the serum is described. Three separate populations of M-component producing cells have been identified. Since a κ→λ chain switch is not demonstrated, the synthesis of IgGκ and IgGλ by two distinct clones is obvious. IgMλ and IgGλ. M-components are synthesized by two different plasma cell populations that could represent two unrelated cell clones or, alternatively, two subclones originated by a common precursor. After chemotherapy the IgGλ M-component is replaced by heavy γ chains without evidence of λ light chains. © 2003 Wiley-Liss, Inc.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
