Treatment of 3′,5′-di-O-acetyl-2′-deoxyinosine 1 with PPh3-CCl4 in the presence of catalytic 1,8diazabicyclo[5.4.0]undec-7-ene (DBU) afforded 6-chloro-9-(2′-deoxy-3 ,5′-di-O-acetyl-β-D-ribofuranosyl)purine 3. Use of an excess of DBU gave the new dimeric bipurine 5 (90%) which proved to be a useful intermediate for obtaining, in one step, [15N-1 ] -2′-deoxyinosine.
REACTION OF 3',5'-DI-O-ACETYL-2'-DEOXYINOSINE WITH THE CHLORINATING AGENT P(PH)3-CCL4 - SYNTHESIS OF THE 6-CHLORODERIVATIVE AND OF A NEW BASE LINKED DIMER, USEFUL INTERMEDIATE TO N-15-1-LABELED 2'-DEOXYINOSINE
MESSERE, Anna;
1994
Abstract
Treatment of 3′,5′-di-O-acetyl-2′-deoxyinosine 1 with PPh3-CCl4 in the presence of catalytic 1,8diazabicyclo[5.4.0]undec-7-ene (DBU) afforded 6-chloro-9-(2′-deoxy-3 ,5′-di-O-acetyl-β-D-ribofuranosyl)purine 3. Use of an excess of DBU gave the new dimeric bipurine 5 (90%) which proved to be a useful intermediate for obtaining, in one step, [15N-1 ] -2′-deoxyinosine.File in questo prodotto:
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