Abstract Neuroinflammation is a protective process of the nervous system triggered by injury, infection, or disease. When particularly prolonged and/or intense, it becomes harmful and exacerbates the damage. Neuroinflammation is the common component of spinal cord injuries, strokes, multiple sclerosis, neuropsychiatric, neurodegenerative, and metabolic diseases. Endocannabinoids promote the resolution of neuroinflammation, and thus, the enhancement of their action could represent the turning point in the therapy of neuroinflammatory-based diseases. Palmitoylethanolamide (PEA) is an N-acylethanolamine (NAE) congener of anandamide showing anti-neuroinflammatory properties. It enhances the activity of endocannabinoids by inhibiting the enzyme responsible for anandamide breakdown. However, the neuroprotective action of PEA is mainly associated with the nuclear peroxisome proliferator-activated receptor-α stimulation. This chapter will describe the effects of PEA and other NAEs in animal models of neuroinflammation-based disorders. Clinical studies on the effects of PEA in neuroinflammation-based diseases will also be described.
Palmitoylethanolamide and other anandamide congeners in neuroinflammation-based disorders: Linking in the endocannabinoid system
Enza Palazzo
;Serena Boccella;Rosmara Infantino;Michela Perrone;Antimo Fusco;Sabatino Maione
2023
Abstract
Abstract Neuroinflammation is a protective process of the nervous system triggered by injury, infection, or disease. When particularly prolonged and/or intense, it becomes harmful and exacerbates the damage. Neuroinflammation is the common component of spinal cord injuries, strokes, multiple sclerosis, neuropsychiatric, neurodegenerative, and metabolic diseases. Endocannabinoids promote the resolution of neuroinflammation, and thus, the enhancement of their action could represent the turning point in the therapy of neuroinflammatory-based diseases. Palmitoylethanolamide (PEA) is an N-acylethanolamine (NAE) congener of anandamide showing anti-neuroinflammatory properties. It enhances the activity of endocannabinoids by inhibiting the enzyme responsible for anandamide breakdown. However, the neuroprotective action of PEA is mainly associated with the nuclear peroxisome proliferator-activated receptor-α stimulation. This chapter will describe the effects of PEA and other NAEs in animal models of neuroinflammation-based disorders. Clinical studies on the effects of PEA in neuroinflammation-based diseases will also be described.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
