Serotonin and Coronary Artery Disease

To the Editor: Two articles1,2 and an editorial3 in the March 7 issue reported a possible role for serotonin in the pathogenesis of clinical coronary ischemia. Golino et al. noted that “it is still uncertain whether serotonin is important in modulating coronary-artery tone in humans.” 1 McFadden et al. reported that the role of serotonin “in human coronary artery disease remains largely speculative.”2 In the accompanying editorial, Hillis and Lange noted that the reported data “suggest that treatment with a serotonin antagonist may be beneficial in patients with [unstable angina].”3 In a previously published report4 we reviewed the case of a. © 1991, Massachusetts Medical Society. All rights reserved.