ISOLATED GENETICALLY MODIFIED CELL POPULATION

The present invention concerns an isolated population of cells characterized by the fact that (I) they comprise at least one exogenous RNA, (II) have the PHD-2 gene inducible silenced, and / or (IlIa) have the UQCRB gene inducible silenced or (IIIb) have the SIRT3 gene inducible overexpressed or (IIIC) have one or more of the following systems modulated by the use of inhibitors or inducers: SOD1 / SOD2 / SOD3 (superoxide dismutase 1 -3), Nrf2 / keepl1 (NF-E2-related transcription factor 2), CAT (catalase), Grx (glutathione-glutaredoxin system), PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1 alpha) FoxOS (forkhead box protein family), Trx (thioredoxin system), NOX-DUOXs (NADPH oxidase family), phox family PRXs (peroxiredoxins), MPO (myeloperoxidase), glutathione peroxidase (GPx); optionally (IV) they include at least one suicide gene, and / or (V) have the gene HIF-1 alpha silenced. This isolated population of cells is useful in the treatment of tissue damage, degenerative diseases, inflammatory and immune disorders, bacterial infections, in gene therapy, in the treatment of viral diseases and tumors. A method for producing said isolated population of cells is a further object of the invention.