Despite the use of systems biology is still at the beginning in the study of complex diseases, the '-omics'strategies are already contributing to novel insights into atherosclerosis and CVDs. The promise of this approach includes disease risk prediction and prevention as well as the possibility of personalized therapy. In this concern, research interest has been recently focused on evaluating the role of endothelial progenitor cells in tissue vascularization and regeneration. This circulating cell population has also been proposed as potential clinical marker for several diseases including cardiovascular ones, where they have begun to be used as a new therapeutic option . Recent in vivo proteomic data suggest a potential effect of acute coronary syndrome in the protein profiles of these cells . These findings suggest that integrated 'omics technologies, including metabolomics, may help to better characterize these cells and understand their biology as well as their pathophysiological role in CVD and tissue regeneration.
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