Triple-negative breast cancers (TNBC) are characterised by an aggressive phenotype and have been associated with poor prognosis. Triple-negative breast cancer patients are unresponsive to current targeted therapies and other treatment options are only partially effective. Therefore, new pharmacological approaches are needed. Given the relevant role of leptin in breast cancer growth and metastasis, leptin system has emerged as a new and promising therapeutic target for breast cancer. Importantly, recent studies provide initial evidence of cAMP elevation as a simple way to neutralize leptin-induced biological effects in TNBC cells, including proliferation and migration. The underlying molecular mechanisms, the potential clinical significance and therapeutic applications by these studies will be presented

INHIBITION OF ONCOGENIC EFFECTS OF LEPTIN BY CAMP ELEVATION IN TRIPLE NEGATIVE BREAST CANCER CELLS

SPINA, Annamaria;Sapio L;NAVIGLIO, Silvio
2014

Abstract

Triple-negative breast cancers (TNBC) are characterised by an aggressive phenotype and have been associated with poor prognosis. Triple-negative breast cancer patients are unresponsive to current targeted therapies and other treatment options are only partially effective. Therefore, new pharmacological approaches are needed. Given the relevant role of leptin in breast cancer growth and metastasis, leptin system has emerged as a new and promising therapeutic target for breast cancer. Importantly, recent studies provide initial evidence of cAMP elevation as a simple way to neutralize leptin-induced biological effects in TNBC cells, including proliferation and migration. The underlying molecular mechanisms, the potential clinical significance and therapeutic applications by these studies will be presented
Spina, Annamaria; Di Maiolo, F; Sapio, L; Sorvillo, L; Naviglio, Silvio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11591/178623
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