In our in vitro system, the rat hypothalamus is highly sensitive to N-methyl-D-aspartate (NMDA) in secreting mammalian gonadotropin-releasing hormone (mGnRH). Indeed, doses equivalent to and up to 20-times lower than the hypothalamic concentration of endogenous NMDA, can significantly increase the amount of GnRH secreted by incubated hypothalamic tissue. L-glutamate (another excitatory amino acid) can also induce the secretion of mGnRH, and the data show for the first time that the post-synaptic biological potency of NMDA in evoking GnRH release is nearly 100-times higher than that of L-glutamate. Further work is in progress to clarify the molecular mechanisms that underlie NMDA's role in modulating mGnRH secretion and release.
NMDA can modulate mGnRH secretion from rat hypothalamus
DI FIORE, Maria Maddalena;
2001
Abstract
In our in vitro system, the rat hypothalamus is highly sensitive to N-methyl-D-aspartate (NMDA) in secreting mammalian gonadotropin-releasing hormone (mGnRH). Indeed, doses equivalent to and up to 20-times lower than the hypothalamic concentration of endogenous NMDA, can significantly increase the amount of GnRH secreted by incubated hypothalamic tissue. L-glutamate (another excitatory amino acid) can also induce the secretion of mGnRH, and the data show for the first time that the post-synaptic biological potency of NMDA in evoking GnRH release is nearly 100-times higher than that of L-glutamate. Further work is in progress to clarify the molecular mechanisms that underlie NMDA's role in modulating mGnRH secretion and release.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
