THE ROLE OF THE ANDROGEN RECEPTOR IN SKELETAL MUSCLE SENESCENCE.

Our study provides new clues that entangle the role of the androgen-induced AR/FlnA complex assembly in skeletal muscle senescence. Findings in C2C12 cells and muscle biopsies from young or old subjects make the AR/FlnA complex a molecular signature for skeletal muscle health. Taken together, these findings suggest that specific perturbation of AR/FlnA complex assembly impairs the androgen effect and commits the cells towards senescence. Overall, our data indicate that FlnA has a permissive role in muscle cell trophism and strongly cooperates with AR in sustaining the androgen action on the health and wellbeing of skeletal muscle. Tracking and decoding the AR/FlnA complex might provide new hints for the identification of therapeutic candidates in sarcopenia, osteosarcopenia, and frailty.