8 Tesi di dottorato

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Intelligent Methods for Human Wellbeing Risk Assessment

Innovative Dietary Strategies: A novel approach to Obesity management and diseases prevention

Abstract Obesity represents a major global health issue, associated with metabolic syndrome, insulin resistance, and chronic inflammation. Identifying effective and sustainable dietary strategies is essential for improving metabolic efficiency and reducing related comorbidities. Recent evidence highlights the role of Orexin-A, a hypothalamic neuropeptide regulating arousal, appetite, and energy expenditure, as a potential biomarker of neuro-metabolic adaptation. This study aimed to evaluate ...

PRELIMINARY INSIGHTS INTO UNUSUAL PATHWAYS IN SENESCENCE: RNA LIGASE AND MITOCHONDRIAL MICROPROTEINS

Cellular senescence is a fundamental biological process that underlies organismal aging and the emergence of degenerative disease. While conventional models attribute senescence primarily to DNA damage, telomere erosion, and oxidative stress, there is now evidence pointing toward additional, nonconventional molecular pathways that sustain the senescent state. This thesis investigates two pathways, including human RNA ligase (C12ORF29) and mitochondrial-derived microproteins (MDPs) conta...

Integrative Meta-Analysis of Transcriptomic Networks Reveals Core Signatures and Master Regulators of Cellular Senescence

Cellular senescence appears as a stable, self-maintaining program rather than a transient stress reflex. To assess how this pattern persists across contexts, seven public human fibroblast RNA-seq datasets were assembled, encompassing both replicative and acute models. Raw count matrices from each dataset were batch-corrected with Surrogate Variable Analysis (SVA) to remove latent technical effects before differential expression modeling. DESeq2 was used to estimate differential expression wit...

Steel exoskeletons for low-impact and Integrated seismic retrofit of existing buildings

A significant portion of Europe's building stock was constructed following World War II. The absence of updates and enhancements has left this constructed environment exceedingly vulnerable to seismic events and energy inefficient. Due to PNRR tax incentives, there is a distinct necessity to delineate and supply qualified professionals with integrated, efficient, prompt, and cost-effective retrofit solutions. These treatments ought to be formulated with a comprehensive approach and grounded i...

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