P150 CENTRAL ADIPOSITY HAS A DETRIMENTAL IMPACT ON TRABECULAR BONE IN OBESE POSTMENOPAUSAL WOMEN: A RETROSPECTIVE STUDY

Objective: To evaluate the effect of visceral adipose tissue (VAT) on bone microarchitecture in postmenopausal obese women. Materials and Methods: In this retrospective study we reported data from medical records of obese postmenopausal women (BMI ≥30 kg/m2) referring to our outpatient rehabilitation service for the prevention and management of osteoporosis over a 3-year period. In these patients we measured BMD at lumbar spine (LS BMD) and at femoral neck (FN BMD), trabecular bone score (TBS), VAT volume and VAT mass. The population was divided into quartiles of VAT volume (VAT < 1.398 cm3; VAT between 1.398 and 1.764 cm3; VAT between 1.765 and 2.371 cm3; VAT > 2.371 cm3). The differences between groups in terms of TBS, according to cutoff proposed by Silva et al. [1], were assessed using SPSS 21.0 to perform the Kruskal-Wallis test for independent samples. Results: We analyzed data of 226 women (mean age 64.56 ± SD 8.42, mean BMI 34.18 ± SD 3.32). There were no statistically significant differences for age between groups (p=0.332). In our population, higher VAT volume was associated with a significant worsening of the trabecular bone microarchitecture (p = 0.003). In particular, in the first quartile, 40.8 % of patients had a TBS≤ 1.200, whereas in the higher quartile 72.2 % of women had degraded microarchitecture. Conclusions: Nowadays, the relationship between adipose tissue and bone is not well understood. Moreover, the bone involvement in obese patients is still controversial. The amount of visceral adipose tissue (VAT) might beone of the pathogenetic factors involved in bone microarchitecture deterioration in obese postmenopausal women. References: 1Silva BC, et al. J Bone Miner Res 2014;29:518.