Introduction/Background Osteoarthritis (OA) is the major cause of joint pain and impaired mobility resulting in a marked reduction of quality of life. It would be of crucial importance to have a clear definition of early OA (EOA) in order to adopt proper preventive measures that might result in better long-term quality of life of affected patients and reduce or delay the need of joint replacement interventions, with the related implications in terms of economic impact on healthcare services. Aim of this systematic review (SR) was to define the state of the art on definition, diagnosis, and management of EOA. Material and Method We carried out an updated systematic review on both PubMed and Embase databases searching for all the studies and researches published in literature (up to the 31st December 2015) which were addressing the issues of EOA definition, diagnosis, and management. The systematic SR has been carried out following the 5 steps summarized by Khan and colleagues in 2003. Results Our SR found out 211 and 447 articles, when searching on PubMed and Embase database, respectively. Among the 132 papers who met our inclusion criteria, only 1 article explicitly addressed the issue of EOA definition, but it was only an expert opinion, while all the other researches were focused on diagnosis or management of EOA. EOA has been defined with regards to the younger age of osteoarthritis onset and radiological damage (grade I-II of the Kellgren and Lawrence classification). Conclusion EOA has been defined with regards to the age of the patient and the precocity of radiologically measureable damages. A clearer classification of EOA based on characteristics and symptoms of affected patients, should be delivered by scientific community in order to better identify subjects who might benefit from innovative therapeutic approaches.

ISPR8-0432 EARLY OSTEOARTHRITIS: DEFINITION, DIAGNOSIS, AND MANAGEMENT. A SYSTEMATIC REVIEW

F. Gimigliano;MORETTI A;G. Iolascon
2018

Abstract

Introduction/Background Osteoarthritis (OA) is the major cause of joint pain and impaired mobility resulting in a marked reduction of quality of life. It would be of crucial importance to have a clear definition of early OA (EOA) in order to adopt proper preventive measures that might result in better long-term quality of life of affected patients and reduce or delay the need of joint replacement interventions, with the related implications in terms of economic impact on healthcare services. Aim of this systematic review (SR) was to define the state of the art on definition, diagnosis, and management of EOA. Material and Method We carried out an updated systematic review on both PubMed and Embase databases searching for all the studies and researches published in literature (up to the 31st December 2015) which were addressing the issues of EOA definition, diagnosis, and management. The systematic SR has been carried out following the 5 steps summarized by Khan and colleagues in 2003. Results Our SR found out 211 and 447 articles, when searching on PubMed and Embase database, respectively. Among the 132 papers who met our inclusion criteria, only 1 article explicitly addressed the issue of EOA definition, but it was only an expert opinion, while all the other researches were focused on diagnosis or management of EOA. EOA has been defined with regards to the younger age of osteoarthritis onset and radiological damage (grade I-II of the Kellgren and Lawrence classification). Conclusion EOA has been defined with regards to the age of the patient and the precocity of radiologically measureable damages. A clearer classification of EOA based on characteristics and symptoms of affected patients, should be delivered by scientific community in order to better identify subjects who might benefit from innovative therapeutic approaches.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11591/419675
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact