As a proof of principle, we have developed a novel surface plasmon resonance (SPR) sensor used to monitor the interaction between a molecularly imprinted polymer (MIP) and a small molecule as the substrate. This plasmonic platform is based on a removable polymethyl methacrylate (PMMA) chip with a thin gold film on the top, two PMMA plastic optical fibers (POFs) and a special holder, designed to obtain the plasmonic phenomenon. We have experimentally tested whether the optical sensitivity is sufficient for monitoring an MIP receptor. The advantage of MIPs is that they can be directly deposited on a flat gold surface by a spin coater machine, without modifying the surface, as needed for the bio-receptors. With this new sensor, it is possible to achieve remote sensing capabilities, by POFs, and also to realize an engineered platform with a removable chip sensor.
A molecularly imprinted polymer on a novel surface plasmon resonance sensor
Zeni L.;Cennamo N.
2019
Abstract
As a proof of principle, we have developed a novel surface plasmon resonance (SPR) sensor used to monitor the interaction between a molecularly imprinted polymer (MIP) and a small molecule as the substrate. This plasmonic platform is based on a removable polymethyl methacrylate (PMMA) chip with a thin gold film on the top, two PMMA plastic optical fibers (POFs) and a special holder, designed to obtain the plasmonic phenomenon. We have experimentally tested whether the optical sensitivity is sufficient for monitoring an MIP receptor. The advantage of MIPs is that they can be directly deposited on a flat gold surface by a spin coater machine, without modifying the surface, as needed for the bio-receptors. With this new sensor, it is possible to achieve remote sensing capabilities, by POFs, and also to realize an engineered platform with a removable chip sensor.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
