NUZZO, TOMMASO
NUZZO, TOMMASO
Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche (DISTABiF)
Abnormal RasGRP1 Expression in the Post-Mortem Brain and Blood Serum of Schizophrenia Patients
2022 De Rosa, A.; Di Maio, A.; Torretta, S.; Garofalo, M.; Giorgelli, V.; Masellis, R.; Nuzzo, T.; Errico, F.; Bertolino, A.; Subramaniam, S.; Rampino, A.; Usiello, A.
Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging
2016 Punzo, D; Errico, F; Cristino, L; Sacchi, S; Keller, S; Belardo, C; Luongo, Livio; Nuzzo, T; Imperatore, R; Florio, E; DE NOVELLIS, Vito; Affinito, O; Migliarini, S; Maddaloni, G; Sisalli, Mj; Pasqualetti, M; Pollegioni, L; Maione, Sabatino; Chiariotti, L; Usiello, Alessandro
Analysis of mRNA and Protein Levels of CAP2, DLG1 and ADAM10 Genes in Post‐Mortem Brain of Schizophrenia, Parkinson’s and Alzheimer’s Disease Patients
2022 Maio, A. D.; De Rosa, A.; Pelucchi, S.; Garofalo, M.; Marciano, B.; Nuzzo, T.; Gardoni, F.; Isidori, A. M.; Di Luca, M.; Errico, F.; De Bartolomeis, A.; Marcello, E.; Usiello, A.
Anti-GluA3 antibodies in frontotemporal dementia: effects on glutamatergic neurotransmission and synaptic failure
2020 Palese, F; Bonomi, E; Nuzzo, T; Benussi, A; Mellone, M; Zianni, E; Cisani, F; Casamassa, A; Alberici, A; Scheggia, D; Padovani, A; Marcello, E; Di Luca, M; Pittaluga, A; Usiello, A; Borroni, B; Gardoni, F
Cerebrospinal fluid and serum d-serine concentrations are unaltered across the whole clinical spectrum of Alzheimer's disease.
2020 Nuzzo, T; Miroballo, M; Casamassa, A; Mancini, A; Gaetani, L; Nisticò, R; Eusebi, P; Katane, M; Homma, H; Calabresi, P; Errico, F; Parnetti, L; Usiello, A.
Cerebrospinal fluid levels of L-glutamate signal central inflammatory neurodegeneration in multiple sclerosis
2021 Stampanoni Bassi, M.; Nuzzo, T.; Gilio, L.; Miroballo, M.; Casamassa, A.; Buttari, F.; Bellantonio, P.; Fantozzi, R.; Galifi, G.; Furlan, R.; Finardi, A.; De Rosa, A.; Di Maio, A.; Errico, F.; Centonze, D.; Usiello, A.
Cerebrospinal fluid, brain, and spinal cord levels of L-aspartate signal excitatory neurotransmission abnormalities in multiple sclerosis patients and experimental autoimmune encephalomyelitis mouse model
2023 Errico, F.; Gilio, L.; Mancini, A.; Nuzzo, T.; Bassi, M. S.; Bellingacci, L.; Buttari, F.; Dolcetti, E.; Bruno, A.; Galifi, G.; Furlan, R.; Finardi, A.; Dimaio, A.; Difilippo, M.; Centonze, D.; Usiello, A.
D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans
2022 Lombardo, Barbara; Pagani, Marco; De Rosa, Arianna; Nunziato, Marcella; Migliarini, Sara; Garofalo, Martina; Terrile, Marta; D'Argenio, Valeria; Galbusera, Alberto; Nuzzo, Tommaso; Ranieri, Annaluisa; Vitale, Andrea; Leggiero, Eleonora; Di Maio, Anna; Barsotti, Noemi; Borello, Ugo; Napolitano, Francesco; Mandarino, Alessandra; Carotenuto, Marco; Heresco-Levy, Uriel; Pasqualetti, Massimo; Malatesta, Paolo; Gozzi, Alessandro; Errico, Francesco; Salvatore, Francesco; Pastore, Lucio; Usiello, Alessandro
Decreased free d -aspartate levels are linked to enhanced d -aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients
2017 Nuzzo, T; Sacchi, S; Errico, F; Keller, S; Palumbo, O; Florio, E; Punzo, D; Napolitano, F; Copetti, M; Carella, M; Chiariotti, L; Bertolino, A; Pollegioni, L; Usiello, Alessandro
Dysfunctional d-aspartate metabolism in BTBR mouse model of idiopathic autism.
2020 Nuzzo, T; Sekine, M; Punzo, D; Miroballo, M; Katane, M; Saitoh, Y; Galbusera, A; Pasqualetti, M; Errico, F; Gozzi, A; Mothet, Jp; Homma, H; Usiello, A.
Free D-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking D-aspartate oxidase activity
2019 Nuzzo, T; Feligioni, M; Cristino, L; Pagano, I; Marcelli, S; Iannuzzi, F; Imperatore, R; D'Angelo, L; Petrella, C; Carella, M; Pollegioni, L; Sacchi, S; Punzo, D; De Girolamo, P; Errico, F; Canu, N; Usiello, A
High performance liquid chromatography determination of l-glutamate, l-glutamine and glycine content in brain, cerebrospinal fluid and blood serum of patients affected by Alzheimer’s disease
2021 Nuzzo, T.; Mancini, A.; Miroballo, M.; Casamassa, A.; Di Maio, A.; Donati, G.; Sansone, G.; Gaetani, L.; Paoletti, F. P.; Isidori, A.; Calabresi, P.; Errico, F.; Parnetti, L.; Usiello, A.
Homeostasis of serine enantiomers is disrupted in the post-mortem caudate putamen and cerebrospinal fluid of living Parkinson's disease patients
2023 Di Maio, A.; Nuzzo, T.; Gilio, L.; Serra, M.; Buttari, F.; Errico, F.; De Rosa, A.; Bassi, M. S.; Morelli, M.; Sasabe, J.; Sulzer, D.; Carta, M.; Centonze, D.; Usiello, A.
Machine Learning algorithm unveils glutamatergic alterations in the post-mortem schizophrenia brain
2022 De Rosa, A.; Fontana, A.; Nuzzo, T.; Garofalo, M.; Di Maio, A.; Punzo, D.; Copetti, M.; Bertolino, A.; Errico, F.; Rampino, A.; de Bartolomeis, A.; Usiello, A.
New evidence on the role of d‐aspartate metabolism in regulating brain and endocrine system physiology: From preclinical observations to clinical applications
2020 Usiello, A; Di Fiore, M. M.; De Rosa, Arianna; Falvo, S; Errico, F; Santillo, A; Nuzzo, T; Chieffi, Gabriella
Nusinersen Induces Disease-Severity-Specific Neurometabolic Effects in Spinal Muscular Atrophy
2022 Errico, Francesco; Marino, Carmen; Grimaldi, Manuela; Nuzzo, Tommaso; Bassareo, Valentina; Valsecchi, Valeria; Panicucci, Chiara; Di Schiavi, Elia; Mazza, Tommaso; Bruno, Claudio; D'Amico, Adele; Carta, Manolo; D'Ursi, Anna Maria; Bertini, Enrico; Pellizzoni, Livio; Usiello, Alessandro
Nusinersen mitigates neuroinflammation in severe spinal muscular atrophy patients
2023 Nuzzo, Tommaso; Russo, Rosita; Errico, Francesco; D’Amico, Adele; Tewelde, Awet G.; Valletta, Mariangela; Hassan, Amber; Tosi, Michele; Panicucci, Chiara; Bruno, Claudio; Bertini, Enrico; Chambery, Angela; Pellizzoni, Livio; Usiello, Alessandro
Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity.
2017 Sacchi S1, 2; DE NOVELLIS, Vito; Paolone, G; Nuzzo, T; Iannotta, M; Belardo, C; Squillace, M; Bolognesi, P; Rosini, E; Motta, Z; Frassineti, M; Bertolino, A; Pollegioni, L; Morari, M; Maione, Sabatino; Errico, F; Usiello, Alessandro
Perturbation of serine enantiomers homeostasis in the striatum of MPTP-lesioned monkeys and mice reflects the extent of dopaminergic midbrain degeneration
2023 Serra, M.; Di Maio, A.; Bassareo, V.; Nuzzo, T.; Errico, F.; Servillo, F.; Capasso, M.; Parekh, P.; Li, Q.; Thiolat, M. -L.; Bezard, E.; Calabresi, P.; Sulzer, D.; Carta, M.; Morelli, M.; Usiello, A.
Prenatal and Early Postnatal Cerebral d-Aspartate Depletion Influences l-Amino Acid Pathways, Bioenergetic processes, and Developmental Brain Metabolism
2020 Grimaldi, Manuela; Marino, Carmen; Buonocore, Michela; Santoro, Angelo; Sommella, Eduardo; Merciai, Fabrizio; Salviati, Emanuela; De Rosa, Arianna; Nuzzo, Tommaso; Errico, Francesco; Campiglia, Pietro; Usiello, Alessandro; D'Ursi, Anna Maria
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Abnormal RasGRP1 Expression in the Post-Mortem Brain and Blood Serum of Schizophrenia Patients | 1-gen-2022 | De Rosa, A.; Di Maio, A.; Torretta, S.; Garofalo, M.; Giorgelli, V.; Masellis, R.; Nuzzo, T.; Errico, F.; Bertolino, A.; Subramaniam, S.; Rampino, A.; Usiello, A. | |
| Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging | 1-gen-2016 | Punzo, D; Errico, F; Cristino, L; Sacchi, S; Keller, S; Belardo, C; Luongo, Livio; Nuzzo, T; Imperatore, R; Florio, E; DE NOVELLIS, Vito; Affinito, O; Migliarini, S; Maddaloni, G; Sisalli, Mj; Pasqualetti, M; Pollegioni, L; Maione, Sabatino; Chiariotti, L; Usiello, Alessandro | |
| Analysis of mRNA and Protein Levels of CAP2, DLG1 and ADAM10 Genes in Post‐Mortem Brain of Schizophrenia, Parkinson’s and Alzheimer’s Disease Patients | 1-gen-2022 | Maio, A. D.; De Rosa, A.; Pelucchi, S.; Garofalo, M.; Marciano, B.; Nuzzo, T.; Gardoni, F.; Isidori, A. M.; Di Luca, M.; Errico, F.; De Bartolomeis, A.; Marcello, E.; Usiello, A. | |
| Anti-GluA3 antibodies in frontotemporal dementia: effects on glutamatergic neurotransmission and synaptic failure | 1-gen-2020 | Palese, F; Bonomi, E; Nuzzo, T; Benussi, A; Mellone, M; Zianni, E; Cisani, F; Casamassa, A; Alberici, A; Scheggia, D; Padovani, A; Marcello, E; Di Luca, M; Pittaluga, A; Usiello, A; Borroni, B; Gardoni, F | |
| Cerebrospinal fluid and serum d-serine concentrations are unaltered across the whole clinical spectrum of Alzheimer's disease. | 1-gen-2020 | Nuzzo, T; Miroballo, M; Casamassa, A; Mancini, A; Gaetani, L; Nisticò, R; Eusebi, P; Katane, M; Homma, H; Calabresi, P; Errico, F; Parnetti, L; Usiello, A. | |
| Cerebrospinal fluid levels of L-glutamate signal central inflammatory neurodegeneration in multiple sclerosis | 1-gen-2021 | Stampanoni Bassi, M.; Nuzzo, T.; Gilio, L.; Miroballo, M.; Casamassa, A.; Buttari, F.; Bellantonio, P.; Fantozzi, R.; Galifi, G.; Furlan, R.; Finardi, A.; De Rosa, A.; Di Maio, A.; Errico, F.; Centonze, D.; Usiello, A. | |
| Cerebrospinal fluid, brain, and spinal cord levels of L-aspartate signal excitatory neurotransmission abnormalities in multiple sclerosis patients and experimental autoimmune encephalomyelitis mouse model | 1-gen-2023 | Errico, F.; Gilio, L.; Mancini, A.; Nuzzo, T.; Bassi, M. S.; Bellingacci, L.; Buttari, F.; Dolcetti, E.; Bruno, A.; Galifi, G.; Furlan, R.; Finardi, A.; Dimaio, A.; Difilippo, M.; Centonze, D.; Usiello, A. | |
| D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans | 1-gen-2022 | Lombardo, Barbara; Pagani, Marco; De Rosa, Arianna; Nunziato, Marcella; Migliarini, Sara; Garofalo, Martina; Terrile, Marta; D'Argenio, Valeria; Galbusera, Alberto; Nuzzo, Tommaso; Ranieri, Annaluisa; Vitale, Andrea; Leggiero, Eleonora; Di Maio, Anna; Barsotti, Noemi; Borello, Ugo; Napolitano, Francesco; Mandarino, Alessandra; Carotenuto, Marco; Heresco-Levy, Uriel; Pasqualetti, Massimo; Malatesta, Paolo; Gozzi, Alessandro; Errico, Francesco; Salvatore, Francesco; Pastore, Lucio; Usiello, Alessandro | |
| Decreased free d -aspartate levels are linked to enhanced d -aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients | 1-gen-2017 | Nuzzo, T; Sacchi, S; Errico, F; Keller, S; Palumbo, O; Florio, E; Punzo, D; Napolitano, F; Copetti, M; Carella, M; Chiariotti, L; Bertolino, A; Pollegioni, L; Usiello, Alessandro | |
| Dysfunctional d-aspartate metabolism in BTBR mouse model of idiopathic autism. | 1-gen-2020 | Nuzzo, T; Sekine, M; Punzo, D; Miroballo, M; Katane, M; Saitoh, Y; Galbusera, A; Pasqualetti, M; Errico, F; Gozzi, A; Mothet, Jp; Homma, H; Usiello, A. | |
| Free D-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking D-aspartate oxidase activity | 1-gen-2019 | Nuzzo, T; Feligioni, M; Cristino, L; Pagano, I; Marcelli, S; Iannuzzi, F; Imperatore, R; D'Angelo, L; Petrella, C; Carella, M; Pollegioni, L; Sacchi, S; Punzo, D; De Girolamo, P; Errico, F; Canu, N; Usiello, A | |
| High performance liquid chromatography determination of l-glutamate, l-glutamine and glycine content in brain, cerebrospinal fluid and blood serum of patients affected by Alzheimer’s disease | 1-gen-2021 | Nuzzo, T.; Mancini, A.; Miroballo, M.; Casamassa, A.; Di Maio, A.; Donati, G.; Sansone, G.; Gaetani, L.; Paoletti, F. P.; Isidori, A.; Calabresi, P.; Errico, F.; Parnetti, L.; Usiello, A. | |
| Homeostasis of serine enantiomers is disrupted in the post-mortem caudate putamen and cerebrospinal fluid of living Parkinson's disease patients | 1-gen-2023 | Di Maio, A.; Nuzzo, T.; Gilio, L.; Serra, M.; Buttari, F.; Errico, F.; De Rosa, A.; Bassi, M. S.; Morelli, M.; Sasabe, J.; Sulzer, D.; Carta, M.; Centonze, D.; Usiello, A. | |
| Machine Learning algorithm unveils glutamatergic alterations in the post-mortem schizophrenia brain | 1-gen-2022 | De Rosa, A.; Fontana, A.; Nuzzo, T.; Garofalo, M.; Di Maio, A.; Punzo, D.; Copetti, M.; Bertolino, A.; Errico, F.; Rampino, A.; de Bartolomeis, A.; Usiello, A. | |
| New evidence on the role of d‐aspartate metabolism in regulating brain and endocrine system physiology: From preclinical observations to clinical applications | 1-gen-2020 | Usiello, A; Di Fiore, M. M.; De Rosa, Arianna; Falvo, S; Errico, F; Santillo, A; Nuzzo, T; Chieffi, Gabriella | |
| Nusinersen Induces Disease-Severity-Specific Neurometabolic Effects in Spinal Muscular Atrophy | 1-gen-2022 | Errico, Francesco; Marino, Carmen; Grimaldi, Manuela; Nuzzo, Tommaso; Bassareo, Valentina; Valsecchi, Valeria; Panicucci, Chiara; Di Schiavi, Elia; Mazza, Tommaso; Bruno, Claudio; D'Amico, Adele; Carta, Manolo; D'Ursi, Anna Maria; Bertini, Enrico; Pellizzoni, Livio; Usiello, Alessandro | |
| Nusinersen mitigates neuroinflammation in severe spinal muscular atrophy patients | 1-gen-2023 | Nuzzo, Tommaso; Russo, Rosita; Errico, Francesco; D’Amico, Adele; Tewelde, Awet G.; Valletta, Mariangela; Hassan, Amber; Tosi, Michele; Panicucci, Chiara; Bruno, Claudio; Bertini, Enrico; Chambery, Angela; Pellizzoni, Livio; Usiello, Alessandro | |
| Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity. | 1-gen-2017 | Sacchi S1, 2; DE NOVELLIS, Vito; Paolone, G; Nuzzo, T; Iannotta, M; Belardo, C; Squillace, M; Bolognesi, P; Rosini, E; Motta, Z; Frassineti, M; Bertolino, A; Pollegioni, L; Morari, M; Maione, Sabatino; Errico, F; Usiello, Alessandro | |
| Perturbation of serine enantiomers homeostasis in the striatum of MPTP-lesioned monkeys and mice reflects the extent of dopaminergic midbrain degeneration | 1-gen-2023 | Serra, M.; Di Maio, A.; Bassareo, V.; Nuzzo, T.; Errico, F.; Servillo, F.; Capasso, M.; Parekh, P.; Li, Q.; Thiolat, M. -L.; Bezard, E.; Calabresi, P.; Sulzer, D.; Carta, M.; Morelli, M.; Usiello, A. | |
| Prenatal and Early Postnatal Cerebral d-Aspartate Depletion Influences l-Amino Acid Pathways, Bioenergetic processes, and Developmental Brain Metabolism | 1-gen-2020 | Grimaldi, Manuela; Marino, Carmen; Buonocore, Michela; Santoro, Angelo; Sommella, Eduardo; Merciai, Fabrizio; Salviati, Emanuela; De Rosa, Arianna; Nuzzo, Tommaso; Errico, Francesco; Campiglia, Pietro; Usiello, Alessandro; D'Ursi, Anna Maria |