MEGCHELENBRINK, Wouter Leonard

MEGCHELENBRINK, Wouter Leonard  

Dipartimento di Medicina di Precisione  

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Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency 1-gen-2020 Bell, E.; Curry, E. W.; Megchelenbrink, W.; Jouneau, L.; Brochard, V.; Tomaz, R. A.; Mau, K. H. T.; Atlasi, Y.; de Souza, R. A.; Marks, H.; Stunnenberg, H. G.; Jouneau, A.; Azuara, V.
Epigenetic modulation of a hardwired 3D chromatin landscape in two naive states of pluripotency 1-gen-2019 Atlasi, Y.; Megchelenbrink, W.; Peng, T.; Habibi, E.; Joshi, O.; Wang, S. -Y.; Wang, C.; Logie, C.; Poser, I.; Marks, H.; Stunnenberg, H. G.
Epigenomic machinery regulating pediatric AML: clonal expansion mechanisms, therapies, and future perspectives 1-gen-2023 Chianese, Ugo; Papulino, Chiara; Megchelenbrink, Wout; Tambaro, Francesco Paolo; Ciardiello, Fortunato; Benedetti, Rosaria; Altucci, Lucia
Estimating metabolic fluxes using a maximum network flexibility paradigm 1-gen-2015 Megchelenbrink, W.; Rossell, S.; Huynen, M. A.; Notebaart, R. A.; Marchiori, E.
Extensive epigenomic integration of the glucocorticoid response in primary human monocytes and in vitro derived macrophages 1-gen-2019 Wang, C.; Nanni, L.; Novakovic, B.; Megchelenbrink, W.; Kuznetsova, T.; Stunnenberg, H. G.; Ceri, S.; Logie, C.
Extensive patient-to-patient single nucleus transcriptome heterogeneity in pheochromocytomas and paragangliomas 1-gen-2022 Brazda, Peter; Ruiz-Moreno, Cristian; Megchelenbrink, Wout L; Timmers, Henri J L M; Stunnenberg, Hendrik G
Involvement of regulated cell deaths in aging and age-related pathologies 1-gen-2024 Della Torre, Laura; Beato, Antonio; Capone, Vincenza; Carannante, Daniela; Verrilli, Giulia; Favale, Gregorio; Del Gaudio, Nunzio; Megchelenbrink, Wouter Leonard; Benedetti, Rosaria; Altucci, Lucia; Carafa, Vincenzo
Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia 1-gen-2022 Zhai, Yanan; Singh, Prashant; Dolnik, Anna; Brazda, Peter; Atlasy, Nader; del Gaudio, Nunzio; Döhner, Konstanze; Döhner, Hartmut; Minucci, Saverio; Martens, Joost; Altucci, Lucia; Megchelenbrink, Wout; Bullinger, Lars; Stunnenberg, Hendrik G.
NOVEL GENES INVOLVED IN NEUROPATHIC PAIN IN PATIENTS 1-gen-2016 Szklarczyk, R; Megchelenbrink, W; Cizek, P; Ledent, M; Velemans, G; Szklarczyk, D; Huynen, M; Momani, R; Gerrits, M; Faber, K; Smeets, B
optGpSampler: An improved tool for uniformly sampling the solution-space of genome-scale metabolic networks 1-gen-2014 Megchelenbrink, W.; Huynen, M.; Marchiori, E.
PC: Epigenetic modulation of a hardwired 3D chromatin landscape in two naive states of pluripotency 1-gen-2019 Atlasi, Yaser; Megchelenbrink, Wout; Peng, Tianran; Habibi, Ehsan; Joshi, Onkar; Wang, Shuang-Yin; Wang, Cheng; Logie, Colin; Poser, Ina; Marks, Hendrik; Stunnenberg, Hendrik G
Predicting human genetic interactions from cancer genome evolution 1-gen-2015 Lu, X.; Megchelenbrink, Wouter Leonard; Notebaart, R. A.; Huynen, M. A.
SPATIAL ORGANIZATION OF THE PEDIATRIC HIGH-GRADE GLIOMA TUMOR-IMMUNE LANDSCAPE 1-gen-2023 van den Broek, T; Hoogendijk, R; Kranendonk, M; Ruiz, C; Megchelenbrink, Wl; Lammers, J; Ries, Mg; Hoving, E; van der Lugt, J; Rios, Ac; Stunnenberg, H; van Vuurden, D; Zomer, A
STARR-seq identifies active, chromatin-masked, and dormant enhancers in pluripotent mouse embryonic stem cells 1-gen-2020 Peng, Tianran; Zhai, Yanan; Atlasi, Yaser; Ter Huurne, Menno; Marks, Hendrik; Stunnenberg, Hendrik G; Megchelenbrink, Wout
Synthetic dosage lethality in the human metabolic network is highly predictive of tumor growth and cancer patient survival 1-gen-2015 Megchelenbrink, W.; Katzir, R.; Lu, X.; Ruppin, E.; Notebaart, R. A.
Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme 1-gen-2021 Jentho, E; Ruiz-Moreno, C; Novakovic, B; Kourtzelis, I; Megchelenbrink, Wl; Martins, R; Chavakis, T; Soares, Mp; Kalafati, L; Guerra, J; Roestel, F; Bohm, P; Godmann, M; Grinenko, T; Eugster, A; Beretta, M; Joosten, Lab; Netea, Mg; Bauer, M; Stunnenberg, Hg; Weis, S
Transcriptional Heterogeneity and Clonal Evolution between Diagnosis and Relapse in Pediatric Acute Myeloid Leukemia 1-gen-2024 Grasso, Cristoforo; Brazda, Peter; te Pas, Brigit M.; Dharmadhikari, Gitanjali; Koedijk, Joost B.; Goemans, Bianca F.; Heidenreich, Olaf; Belderbos, Mirjam E.; Zwaan, C. Michel; Stunnenberg, Hendrik G.; Megchelenbrink, Wout
WeGET: Predicting new genes for molecular systems by weighted co-expression 1-gen-2016 Szklarczyk, R.; Megchelenbrink, W.; Cizek, P.; Ledent, M.; Velemans, G.; Szklarczyk, D.; Huynen, M. A.
β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance 1-gen-2016 Novakovic, B.; Habibi, E.; Wang, S. -Y.; Arts, R. J. W.; Davar, R.; Megchelenbrink, W.; Kim, B.; Kuznetsova, T.; Kox, M.; Zwaag, J.; Matarese, F.; van Heeringen, S. J.; Janssen-Megens, E. M.; Sharifi, N.; Wang, C.; Keramati, F.; Schoonenberg, V.; Flicek, P.; Clarke, L.; Pickkers, P.; Heath, S.; Gut, I.; Netea, M. G.; Martens, J. H. A.; Logie, C.; Stunnenberg, H. G.