IRIS

MEGCHELENBRINK, Wouter Leonard

MEGCHELENBRINK, Wouter Leonard  

Dipartimento di Medicina di Precisione  

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METTL16-mediated inhibition of MXD4 promotes leukemia through activation of the MYC-MAX axis 1-gen-2025 Bove, Guglielmo; Babaei, Mehrad; Bueno-Costa, Alberto; Amin, Sajid; Simonelli, Nicla; Benedetti, Rosaria; Dell'Aversana, Carmela; Conte, Mariarosaria; Montella, Liliana; Summa, Vincenzo; Brindisi, Margherita; Del Sorbo, Maria Rosaria; Crepaldi, Marco; Favale, Gregorio; Profitos-Peleja, Nuria; Carafa, Vincenzo; Roué, Gaël; Ciardiello, Fortunato; Capuano, Annalisa; Stunnenberg, Hendrik G; Megchelenbrink, Wouter L; Nebbioso, Angela; Esteller, Manel; Altucci, Lucia; Del Gaudio, Nunzio
Single‐cell multi‐omics characterize colorectal tumors, adjacent healthy tissue and matched (tumor) organoids identifying CRC‐unique features 1-gen-2025 Yu, Zhijun; Derksen, Merel; Te Pas, Brigit M.; Ladstätter, Sabrina; Overmeer, Rene; Brazda, Peter; Van De Wetering, Marc; Pourfarzad, Farzin; Vries, Robert G. J.; Megchelenbrink, Wout; Bock, Christoph; Altucci, Lucia; Stunnenberg, Hendrik G.
Systemic inflammation impairs myelopoiesis and interferon type I responses in humans 1-gen-2025 Keramati, Farid; Leijte, Guus P; Bruse, Niklas; Grondman, Inge; Habibi, Ehsan; Ruiz-Moreno, Cristian; Megchelenbrink, Wout; Peters van Ton, Annemieke M; Heesakkers, Hidde; Bremmers, Manita E; van Grinsven, Erinke; Tesselaar, Kiki; van Staveren, Selma; van der Velden, Walter J; Preijers, Frank W; Te Pas, Brigit; van de Loop, Raoul; Gerretsen, Jelle; Netea, Mihai G; Stunnenberg, Hendrik G; Pickkers, Peter; Kox, Matthijs
Deregulation of new cell death mechanisms in Leukemia 1-gen-2024 Favale, Gregorio; Donnarumma, Federica; Capone, Vincenza; DELLA TORRE, Laura; Beato, Antonio; Carannante, Daniela; Verrilli, Giulia; Nawaz, Asmat; Grimaldi, Francesco; Carla De Simone, Maria; DEL GAUDIO, Nunzio; Megchelenbrink, Wouter Leonard; Caraglia, Michele; Benedetti, Rosaria; Altucci, Lucia; Carafa, Vincenzo
Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids 1-gen-2024 Kluiver, Thomas A; Lu, Yuyan; Schubert, Stephanie A; Kraaier, Lianne J; Ringnalda, Femke; Lijnzaad, Philip; Demartino, Jeff; Megchelenbrink, Wouter L; Amo-Addae, Vicky; Eising, Selma; de Faria, Flavia W; Münter, Daniel; van de Wetering, Marc; Kerl, Kornelius; Duiker, Evelien; van den Heuvel, Marius C; de Meijer, Vincent E; de Kleine, Ruben H; Molenaar, Jan J; Margaritis, Thanasis; Stunnenberg, Hendrik G; de Krijger, Ronald R; Zsiros, József; Clevers, Hans; Peng, Weng Chuan
Inverse FASN and LDHA correlation drives metabolic resistance in breast cancer 1-gen-2024 Papulino, Chiara; Chianese, Ugo; Ali, Ahmad; Favale, Gregorio; Tuccillo, Concetta; Ciardiello, Fortunato; Di Mauro, Annabella; Mignogna, Chiara; Ferrara, Gerardo; Budillon, Alfredo; Megchelenbrink, Wouter Leonard; Del Gaudio, Nunzio; Conte, Mariarosaria; Merciai, Fabrizio; Campiglia, Pietro; Altucci, Lucia; Carafa, Vincenzo; Sommella, Eduardo; Benedetti, Rosaria
Involvement of regulated cell deaths in aging and age-related pathologies 1-gen-2024 Della Torre, Laura; Beato, Antonio; Capone, Vincenza; Carannante, Daniela; Verrilli, Giulia; Favale, Gregorio; Del Gaudio, Nunzio; Megchelenbrink, Wouter Leonard; Benedetti, Rosaria; Altucci, Lucia; Carafa, Vincenzo
The m6A-independent role of epitranscriptomic factors in cancer 1-gen-2024 Bove, Guglielmo; Crepaldi, Marco; Amin, Sajid; Megchelenbrink, Wouter Leonard; Nebbioso, Angela; Carafa, Vincenzo; Altucci, Lucia; DEL GAUDIO, Nunzio
Epigenomic machinery regulating pediatric AML: clonal expansion mechanisms, therapies, and future perspectives 1-gen-2023 Chianese, Ugo; Papulino, Chiara; Megchelenbrink, Wout; Tambaro, Francesco Paolo; Ciardiello, Fortunato; Benedetti, Rosaria; Altucci, Lucia
SPATIAL ORGANIZATION OF THE PEDIATRIC HIGH-GRADE GLIOMA TUMOR-IMMUNE LANDSCAPE 1-gen-2023 van den Broek, T; Hoogendijk, R; Kranendonk, M; Ruiz, C; Megchelenbrink, Wl; Lammers, J; Ries, Mg; Hoving, E; van der Lugt, J; Rios, Ac; Stunnenberg, H; van Vuurden, D; Zomer, A
Transcriptional Heterogeneity and Clonal Evolution between Diagnosis and Relapse in Pediatric Acute Myeloid Leukemia 1-gen-2023 Grasso, Cristoforo; Brazda, Peter; te Pas, Brigit M.; Dharmadhikari, Gitanjali; Koedijk, Joost B.; Goemans, Bianca F.; Heidenreich, Olaf; Belderbos, Mirjam E.; Zwaan, C. Michel; Stunnenberg, Hendrik G.; Megchelenbrink, Wout
Extensive patient-to-patient single nucleus transcriptome heterogeneity in pheochromocytomas and paragangliomas 1-gen-2022 Brazda, Peter; Ruiz-Moreno, Cristian; Megchelenbrink, Wout L; Timmers, Henri J L M; Stunnenberg, Hendrik G
Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia 1-gen-2022 Zhai, Yanan; Singh, Prashant; Dolnik, Anna; Brazda, Peter; Atlasy, Nader; del Gaudio, Nunzio; Döhner, Konstanze; Döhner, Hartmut; Minucci, Saverio; Martens, Joost; Altucci, Lucia; Megchelenbrink, Wout; Bullinger, Lars; Stunnenberg, Hendrik G.
Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme 1-gen-2021 Jentho, E; Ruiz-Moreno, C; Novakovic, B; Kourtzelis, I; Megchelenbrink, Wl; Martins, R; Chavakis, T; Soares, Mp; Kalafati, L; Guerra, J; Roestel, F; Bohm, P; Godmann, M; Grinenko, T; Eugster, A; Beretta, M; Joosten, Lab; Netea, Mg; Bauer, M; Stunnenberg, Hg; Weis, S
Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency 1-gen-2020 Bell, E.; Curry, E. W.; Megchelenbrink, W.; Jouneau, L.; Brochard, V.; Tomaz, R. A.; Mau, K. H. T.; Atlasi, Y.; de Souza, R. A.; Marks, H.; Stunnenberg, H. G.; Jouneau, A.; Azuara, V.
STARR-seq identifies active, chromatin-masked, and dormant enhancers in pluripotent mouse embryonic stem cells 1-gen-2020 Peng, Tianran; Zhai, Yanan; Atlasi, Yaser; Ter Huurne, Menno; Marks, Hendrik; Stunnenberg, Hendrik G; Megchelenbrink, Wout
Epigenetic modulation of a hardwired 3D chromatin landscape in two naive states of pluripotency 1-gen-2019 Atlasi, Y.; Megchelenbrink, W.; Peng, T.; Habibi, E.; Joshi, O.; Wang, S. -Y.; Wang, C.; Logie, C.; Poser, I.; Marks, H.; Stunnenberg, H. G.
Extensive epigenomic integration of the glucocorticoid response in primary human monocytes and in vitro derived macrophages 1-gen-2019 Wang, C.; Nanni, L.; Novakovic, B.; Megchelenbrink, W.; Kuznetsova, T.; Stunnenberg, H. G.; Ceri, S.; Logie, C.
PC: Epigenetic modulation of a hardwired 3D chromatin landscape in two naive states of pluripotency 1-gen-2019 Atlasi, Yaser; Megchelenbrink, Wout; Peng, Tianran; Habibi, Ehsan; Joshi, Onkar; Wang, Shuang-Yin; Wang, Cheng; Logie, Colin; Poser, Ina; Marks, Hendrik; Stunnenberg, Hendrik G
NOVEL GENES INVOLVED IN NEUROPATHIC PAIN IN PATIENTS 1-gen-2016 Szklarczyk, R; Megchelenbrink, W; Cizek, P; Ledent, M; Velemans, G; Szklarczyk, D; Huynen, M; Momani, R; Gerrits, M; Faber, K; Smeets, B