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TWENTYFOUR-MONTH AZATHIOPRINE AS MAINTENANCE THERAPY IN PATIENTS WITH SYSTEMIC SCLEROSIS-INTERSTITIAL LUNG DISEASE TREATED WITH LOW DOSE CYCLOPHOSPHAMIDE PULSE THERAPY
2009 Abignano, G.; Cuomo, Giovanna; Iudici, M.; Petrillo, A.; Valentini, G.
Ultrasonographic features of the hand and wrist in systemic sclerosis
2009 Cuomo, Giovanna; Zappia, M; Abignano, G; Iudici, M; Rotondo, Antonio; Valentini, Gabriele
Association of a functional polymorphism in the matrix metalloproteinase-12 promoter region with systemic sclerosis in an Italian population
2010 Manetti, M; IBBA MANNESCHI, L; Fatini, C; Guiducci, S; Cuomo, Giovanna; Bonino, C; Bazzichi, L; Liakouli, V; Giacomelli, R; Abbate, R; Bombardieri, S; Montecucco, C; Valentini, Gabriele; MATUCCI CERINIC, M.
[Survival and death causes in 251 systemic sclerosis patients from a single Italian center].
2010 Vettori, Serena; Cuomo, Giovanna; Abignano, G; Iudici, M; Valentini, Gabriele
The β-fibrinogen -455 G>A gene polymorphism is associated with peripheral vascular injury in systemic sclerosis patients
2010 Vettori, Serena; Cirillo, F; Cuomo, Giovanna; DI MINNO, G; Valentini, Gabriele
THE PROLIFERATIVE TRANSCRIPTIONAL FACTORS FOXE3 IS THE TARGET OF ANTI-CENP-A ANTIBODIES (AB) AND IDENTIFIES A SUBSET OF ANTI-CENP AB POSITIVE SYSTEMIC SCLEROSIS PATIENTS
2010 Perosa, F.; Vicenti, C.; Racanelli, V.; Cuomo, Giovanna; Valentini, G.; Dammacco, F.
[THU0309] CLINICAL MANIFESTATIONS IN LATE VS EARLY –ONSET SYSTEMIC SCLEROSIS (SSC) G. Cuomo, M. Iudici, G. Abignano, G. Valentini. Second Universty of Naples, Rheumatology Unit, Naples, Italy Background: Differences have been so far pointed out in the clinical manifestations and disease course in patients with a number of autoimmune rheumatic diseases and different age at onset (1-3). Objectives: To investigate the occurrence of differences between early and late onset SSc. Methods: 260 SSc patients (233 females) with a median age at the onset of the disease of 40.5 years (range 8-74) were consecutively admitted to a tertiary centre from November 1st 2000 to October 31st 2008. They were divided into 2 groups: early onset (<40.5 years) and late onset (≥40.5 years). Differences in each of the epidemiological, clinical and serological aspects collected in all the patients at admission were analysed. Results: Table 1 lists the significant differences detected between the 2 groups. Early onset patients were found to have a longer disease duration at presentation, a higher prevalence of anti-Scl70 positivity and a higher prevalence of scleroderma renal crisis; a lower prevalence of antinucleolar antibody positivity; a lower percentage of pulmonary hypertension; a lower HAQ-DI and a lower prevalence of heart involvement. No difference was detected in clinical subset distribution. Late onset (138) Early onset (122) p Disease duration mean (sd) 6 (6) 10 (10) 0.003 Range (median) 0.5-26 (5) 0.5-45 (6) Serological subset Scl70 43 54 0.04 Nucleolar 9 23 0.004 PAPs ≥40mmHG (echocardiography) 14/124 3/119 0.01 HAQ-DI mean (sd) 0.65 (0.7) 0.5 (0.7) 0.037 Range (median) 0-0.275 (0.375) 0-0.25 (0.125) Severity scale Late onset (138) Early onset(122) p 0-1 2-3-4 0-1 2-3-4 Heart 117 21 121 1 <0.0001 Kidney 138 0 117 5 0.02 Conclusion: Our study demonstrate that similarly to systemic lupus erithematosus and rheumatoid arthritis, distinct differences related to age at onset also occur in SSc patients. References: • Calvo-Alen J. et al, Clin Rheumatol 2005 • Lalani S. et al, J Rheumatol 2010 • Ho CT et al, Ann Rheum 1998 Disclosure of Interest: None declared Citation: Ann Rheum Dis 2010;69(Suppl3):247 Session: Scleroderma, Myositis and related syndromes
2010 Cuomo, Giovanna; Iudici, M.; Abignano, G.; Valentini, G.
[OP0219] EUROPEAN SCLERODERMA STUDY GROUP (ESCSG) ACTIVITY INDEX IS CORRELATED TO QUALITY OF LIFE MEASURES BOTH AT ADMISSION AND OVERTIME M. Iudici, G. Cuomo, G. Abignano, G. Valentini. Rheumatology Unit, Second University of Naples, Naples, Italy Objectives: EScSG activity index has been validated for construct validity [1]. Its discriminant validity awaits to be investigated. In order to address this aspect, we investigated the relationship between the activity index and Health Assessment Questionnaire-Disability Index, physical and mental component scores (PCS and MCS) of Short Form-36 (SF36). Methods: 140 SSc patients consecutively admitted at tertiary center were investigated for EScSG activity index, HAQ-DI and PCS and MCS of SF36 at enrolment and after 1 year. The change (Δ) for each of the all measures was calculated. Results: EScSG activity index was found to be correlated to HAQ-DI, PCS and MCS both at admission (Rho=0.49, p=0.0003; Rho= -0.40, p<0.0001; Rho= -0.29, p=0.001, respectively) and after 1 year (Rho=0,64, p<0,0001; Rho= -0.29, p=0.001; Rho=-0.18, p=0.046 respectively). Moreover, the change between the value of the activity index at 1 year and that at admission (Δ activity index) was significantly correlated to ΔHAQ-DI, ΔPCS, ΔMCS (Rho=0,43, p=0.002; Rho=0,56, p<0.0001; Rho=0.48, p=0.002, respectively). Conclusion: HAQ-DI and SF36 (PCS and MCS) are considered to be validated outcome measure in SSc. Our results further support the construct validity of EScSG activity index and are for the first time underline its discriminant validity. References: • Valentini G. et al. European Scleroderma Study Group to define disease activity criteria for systemic sclerosis. III. Assessment of the construct validity of the preliminary activity criteria. Ann Rheum Dis 2003. Disclosure of Interest: None declared Citation: Ann Rheum Dis 2010;69(Suppl3):128 Session: Abstract Session: Modern prespective in systemic sclerosis
2010 Iudici, M.; Cuomo, Giovanna; Abignano, G.; Valentini, G.
Impaired exercise performance in systemic sclerosis and its clinical correlations
2010 Cuomo, Giovanna; Santoriello, C.; Polverino, F.; Ruocco, L.; Valentini, Gabriele; Polverino, M.
CROSS-SECTIONAL EVALUATION OF CHEMOKINE PROFILE IN EARLY AND DEFINITE SYSTEMIC SCLEROSIS
2010 Vettori, Serena; Cuomo, Giovanna; Abignano, G.; Iudici, M.; D'Aiuto, E.; DE PALMA, Raffaele; Valentini, G.
European Scleroderma Study Group (ESCSG) Activity Index is correlated to quality of life measures both at admission and overtime
2010 Valentini, Gabriele; Iudici, Michele; Abignano, Giuseppina; Vettori, Serena; Cuomo, Giovanna
Clinical and subclinical atherosclerosis in systemic sclerosis: consequences of previous corticosteroid treatment.
2010 Vettori, Serena; Maresca, L.; Cuomo, Giovanna; Abbadessa, Salvatore; Leonardo, G.; Valentini, Gabriele
ELF Score: A Validated Serum Test Strongly Predictive of Fibrosis in Systemic Sclerosis.
2011 Abignano, Giuseppina; Cuomo, Giovanna; Buch, Maya H.; Rosenberg, William M.; Valentini, Gabriele; Emery, Paul; Galdo, Francesco Del
A genetic variation located in the promoter region of the UPAR (CD87) gene is associated with the vascular complications of systemic sclerosis
2011 Manetti, M; Allanore, Y; Revillod, L; Fatini, C; Guiducci, S; Cuomo, Giovanna; Bonino, C; Riccieri, V; Bazzichi, L; Liakouli, V; Cipriani, P; Giacomelli, R; Abbate, R; Bombardieri, S; Valesini, G; Montecucco, C; Valentini, Gabriele; IBBA MANNESCHI, L; MATUCCI CERINIC, M.
ELF TEST: A PROMISING SURROGATE OUTCOME MEASURE IN SYSTEMIC SCLEROSIS
2011 G., Abignano; Cuomo, Giovanna; Buch, M.; Rosenberg, W. M.; Valentini, G.; Emery, P.
THE ROLE OF HEALTH ASSESSMENT QUESTIONNAIRE-DISABILITY INDEX (HAQ-DI) IN PREDICTING SURVIVAL IN PATIENTS AFFECTED BY SYSTEMIC SCLEROSIS (SSC)
2011 Iudici, M.; Cuomo, Giovanna; D'Abrosca, V.; Irace, R.; Valentini, G.
COURSE OF HBV INFECTION IN PATIENTS UNDERGOING TRADITIONAL DISEASE-MODIFYING ANTI-RHEUMATIC DRUGS (DMARDS)
2011 Urraro, T.; Cuomo, Giovanna; Valentini, G.
Inappropriate exercise-induced increase in pulmonary artery pressure in patients with systemic sclerosis.
2011 D'Alto, M; Ghio, S; D'Andrea, A; Pazzano, As; Argiento, P; Camporotondo, R; Allocca, F; Scelsi, L; Cuomo, Giovanna; Caporali, R; Cavagna, L; Valentini, Gabriele; Calabro', Raffaele
Early systemic sclerosis: assessment of clinical and pre-clinical organ involvement in patients with different disease features
2011 Valentini, Gabriele; Cuomo, Giovanna; Abignano, G; Petrillo, A; Vettori, Serena; Capasso, A; Cozzolino, D; DEL GENIO, Gianmattia; Santoriello, C.
A SCLERODERMA PATIENT WITH SWOLLEN AND TENDER JOINTS OF BOTH HANDS
2011 Valentini, Gabriele; Cuomo, Giovanna; D'Abrosca, V; Cappabianca, Salvatore
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