PREDICTED CREATININE CLEARANCE TO ASSESS GLOMERULAR-FILTRATION RATE IN CHRONIC RENAL-DISEASE IN HUMANS

The work was designed to assess the suitability of both measured endogenous creatinine clearance (C(CR)) and predicted creatinine clearance (P-C(CR)) to evaluate GFR in chronic renal disease (CRD) by utilizing the renal clearance of inulin (C(IN)) as gold standard. A total of 124 subjects were studied (62 healthy, 62 with CRF). C(CR) significantly overestimated GFR in healthy subjects as well as in CRF, whereas P-C(CR) was identical to GFR. The C(CR)/C(IN) ratio which calculates the fractional creatinine clearance and provides a rough estimation of the contribution of creatinine secretion in explaining the differences between C(CR) and GFR was increased in CRD and especially in CRD of glomerular origin. The ration P-C(CR)/C(IN) was significantly lower than C(CR)/C(IN) in healthy subjects and in patients with CRD of glomerular origin. The data are against the use of C(CR) in assessing GFR in healthy subjects and in patients with CRD.