Exogenus prednisolone is biotransformed in cultures of the green alga T76 Scenedesmus quadricauda in two main bioproducts, which have been purified by chromatographic processes and identified by spectroscopic means. The first compound is the 5α-hydroxyderivative of prednisolone and might be formed by a simple hydration of the Δ4 double bond. The latter rises from a complex rearrangement. It is rather unstable and undergoes oxidation by atmospheric oxygen to a hydroperoxide which slowly decays to the corresponding hydroxyderivative.
Prednisolone biotransformation by the green alga T76 Scenedesmus quadricauda
FIORENTINO, Antonio;
1997
Abstract
Exogenus prednisolone is biotransformed in cultures of the green alga T76 Scenedesmus quadricauda in two main bioproducts, which have been purified by chromatographic processes and identified by spectroscopic means. The first compound is the 5α-hydroxyderivative of prednisolone and might be formed by a simple hydration of the Δ4 double bond. The latter rises from a complex rearrangement. It is rather unstable and undergoes oxidation by atmospheric oxygen to a hydroperoxide which slowly decays to the corresponding hydroxyderivative.File in questo prodotto:
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