One new and six known flavone glycosides were isolated from the MeOH extract of Melilotus neapolitana Ten. The new compound, identified as 7-O-β-D-glucopyranosyloxy-4′,5-dihydroxy-3-[O-α-L- rhamnopyranosyl-(1→6)-3-O-β-D-glucopyranosyloxy] flavone (1) by 1D and 2D NMR techniques and mass spectra, was isolated along with kaempferol-3-O-rutinoside (2), kaempferol-3-O-glucoside (3), rutin (4), quercetin-3-O-glucoside (5), isorhamnetin-3-O-rutinoside (6), and isorhamnetin-3-O-glucoside (7). The antioxidant and radical scavenging activities of these compounds and the whole crude methanol extract were evaluated. The organic extract can inhibit MDA marker's synthesis by 57%. All the metabolites displayed good reducing power, with the kaempferol (2,3) and isorhamnetin derivatives (6,7) being less active than the corresponding quercetin derivatives 4,5. © 2007 by MDPI.

Reactive oxygen species scavenging activity of flavone glycosides from Melilotus neapolitana

FIORENTINO, Antonio;D'ABROSCA, Brigida;PACIFICO, Severina;MONACO, Pietro
2007

Abstract

One new and six known flavone glycosides were isolated from the MeOH extract of Melilotus neapolitana Ten. The new compound, identified as 7-O-β-D-glucopyranosyloxy-4′,5-dihydroxy-3-[O-α-L- rhamnopyranosyl-(1→6)-3-O-β-D-glucopyranosyloxy] flavone (1) by 1D and 2D NMR techniques and mass spectra, was isolated along with kaempferol-3-O-rutinoside (2), kaempferol-3-O-glucoside (3), rutin (4), quercetin-3-O-glucoside (5), isorhamnetin-3-O-rutinoside (6), and isorhamnetin-3-O-glucoside (7). The antioxidant and radical scavenging activities of these compounds and the whole crude methanol extract were evaluated. The organic extract can inhibit MDA marker's synthesis by 57%. All the metabolites displayed good reducing power, with the kaempferol (2,3) and isorhamnetin derivatives (6,7) being less active than the corresponding quercetin derivatives 4,5. © 2007 by MDPI.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11591/193356
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