Gliadins are central in the pathogenesis of coeliac disease. The paper describes the ability of gliadin peptides to delay EGF-R inactivation through interference with the endocytic pathway, thus amplifying the signaling mediated by EGF-R, including proliferative alterations of the small intestine in coeliac disease.
Growth factor-like activity of gliadin, an alimentary protein: implications for celiac disease (CD)
CASTORIA, Gabriella;
2007
Abstract
Gliadins are central in the pathogenesis of coeliac disease. The paper describes the ability of gliadin peptides to delay EGF-R inactivation through interference with the endocytic pathway, thus amplifying the signaling mediated by EGF-R, including proliferative alterations of the small intestine in coeliac disease.File in questo prodotto:
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