Papillomatosis cutis arising on an immuno-compromised district due to paraplegia

The immunocompromised district is a novel concept referring to a site in which there is an obstacle to the normal trafficking of immunocompetent cells through lymphatic channels, or an interference with the signals that the neuropeptides and neurotransmitters, released by peripheral nerves, send to cell membrane receptors of immunocompetent cells. The connection between immunocompromised district and benign proliferative diseases has never been considered. Lymphostasis and paraplegia have a common denominator: the induction of a regional immunocompromise. There is a well-founded suspicion that papillomatosis cutis ‘lymphostatica’ in patients affected both by lymphostasis and with paraplegia could be hinged upon this common mechanism. The altered production of neuroimmunomediators, cytokines and growth factors could explain the genesis of the hyperproliferative stimulus underlying the appearance of a verrucous proliferation like papillomatosis cutis.