Although it has been demonstrated that diabetes mellitus may enhance apoptosis in myocardial (4) and endothelial cells (5), still, no evidence exists in humans about the potential role of diabetes in the evolution of diabetic atherosclerotic plaques toward instability by enhancing VSMC apoptosis. We hypothesize that by enhancing the proinflammatory cytokines, diabetes may exert proapoptotic effects on VSMCs of atherosclerotic plaque. To address these issues, cell death by apoptosis and expression and localization of TNF-9 and IL-1b was evaluated in carotid plaques of asymptomatic diabetic and nondiabetic patients. The study group consisted of 26 type 2 diabetic and 30 nondiabetic patients enlisted to undergo carotid endarterectomy for asymptomatic extracranial high-grade (.70%) internal carotid artery stenosis

The vascular smooth muscle cells apoptosis in asymptomatic diabetic carotid plaques: Role of glycemic control

MARFELLA, Raffaele;DI FILIPPO, Clara;BALDI, Alfonso;SASSO, Ferdinando Carlo;NICOLETTI, Giovanni Francesco;D'ANDREA, Francesco;ROSSI, Francesco;D'AMICO, Michele
2006

Abstract

Although it has been demonstrated that diabetes mellitus may enhance apoptosis in myocardial (4) and endothelial cells (5), still, no evidence exists in humans about the potential role of diabetes in the evolution of diabetic atherosclerotic plaques toward instability by enhancing VSMC apoptosis. We hypothesize that by enhancing the proinflammatory cytokines, diabetes may exert proapoptotic effects on VSMCs of atherosclerotic plaque. To address these issues, cell death by apoptosis and expression and localization of TNF-9 and IL-1b was evaluated in carotid plaques of asymptomatic diabetic and nondiabetic patients. The study group consisted of 26 type 2 diabetic and 30 nondiabetic patients enlisted to undergo carotid endarterectomy for asymptomatic extracranial high-grade (.70%) internal carotid artery stenosis
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11591/188246
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