SUMMARY. (A) A reduced activity of microsomal triglyceride transfer protein (MTP), a key enzyme of assembly ⁄ secretion of lipoproteins, is related to HCV steatosis. Host genetic background may influence development of steatosis. The aim of the study was to investigate the association between MTP- 493 G ⁄ T gene polymorphism, fat liver accumulation and fibrosis progression in HCV infected patients. A total of 102 naı¨ve patients with liver biopsy proven chronic hepatitis C were evaluated for MTP-493 G⁄ T gene polymorphism, HCV RNA, HCV genotype, HOMA-IR, serum adiponectin, TNF-a and serum lipid levels. HCV genotype 3 infected patients carrying the T allele of the MTP gene polymorphism showed higher degree of steatosis than those carrying GG genotype (3.45 ± 0.37 vs 1.30 ± 0.45, respectively; P < 0.001). MTP *T* allele carriers also had higher HCV RNA serum levels (P < 0.01) and hepatic fibrosis (P < 0.001). Irrespective of MTP genotype, patients with HCV genotype 3 had lower levels of cholesterol, ApoB, HDL and LDL. In HCV genotype non-3 infected patients no parameters were associated with MTP gene polymorphism. In conclusion the presence of T allele of MTP-493G ⁄ T gene polymorphism predisposes patients infested with HCV genotype 3 to develop higher degree of fatty liver accumulation.

Microsomal triglyceride transfer protein (MTP) -493G/T gene polymorphism contributes to fat liver accumulation in HCV genotype 3 infected patients

ZAMPINO, Rosa;INGROSSO, Diego;DURANTE MANGONI, Emanuele;ADINOLFI, Luigi Elio
2008

Abstract

SUMMARY. (A) A reduced activity of microsomal triglyceride transfer protein (MTP), a key enzyme of assembly ⁄ secretion of lipoproteins, is related to HCV steatosis. Host genetic background may influence development of steatosis. The aim of the study was to investigate the association between MTP- 493 G ⁄ T gene polymorphism, fat liver accumulation and fibrosis progression in HCV infected patients. A total of 102 naı¨ve patients with liver biopsy proven chronic hepatitis C were evaluated for MTP-493 G⁄ T gene polymorphism, HCV RNA, HCV genotype, HOMA-IR, serum adiponectin, TNF-a and serum lipid levels. HCV genotype 3 infected patients carrying the T allele of the MTP gene polymorphism showed higher degree of steatosis than those carrying GG genotype (3.45 ± 0.37 vs 1.30 ± 0.45, respectively; P < 0.001). MTP *T* allele carriers also had higher HCV RNA serum levels (P < 0.01) and hepatic fibrosis (P < 0.001). Irrespective of MTP genotype, patients with HCV genotype 3 had lower levels of cholesterol, ApoB, HDL and LDL. In HCV genotype non-3 infected patients no parameters were associated with MTP gene polymorphism. In conclusion the presence of T allele of MTP-493G ⁄ T gene polymorphism predisposes patients infested with HCV genotype 3 to develop higher degree of fatty liver accumulation.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11591/186909
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