Fifty-nine secondary metabolites have been isolated from Cydonia vulgaris peels and characterised on the basis of their spectroscopic features. Among them, five metabolites, 3β-(18-hydroxylinoleoyl)-28-hydroxyurs-12-ene (12), 3β-linoleoylurs-12-en-28-oic acid (15), 3β-oleoyl-24-hydroxy-24-ethylcholesta-5,28(29)-diene (24), tiglic acid 1-O-β-d-glucopyranoside (35), and 6,9-dihydroxymegastigmasta-5,7-dien-3-one 9-O-β-d-gentiobioside (46), have been isolated and elucidated for the first time. All of the compounds were tested for their radical-scavenging and antioxidant activities by measuring their capacity to scavenge the 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical, and anion superoxide radical and to induce the reduction of Mo(VI) to Mo(V). The antiproliferative activity of all the most abundant compounds by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) bioassay on murine B16-F1 melanoma cells has been also assessed. © 2009 Elsevier Ltd. All rights reserved.

Antioxidant and antiproliferative activities of phytochemicals from Quince (Cydonia vulgaris) peels

D'ABROSCA, Brigida;FIORENTINO, Antonio
;
MONACO, Pietro;PACIFICO, Severina
2010

Abstract

Fifty-nine secondary metabolites have been isolated from Cydonia vulgaris peels and characterised on the basis of their spectroscopic features. Among them, five metabolites, 3β-(18-hydroxylinoleoyl)-28-hydroxyurs-12-ene (12), 3β-linoleoylurs-12-en-28-oic acid (15), 3β-oleoyl-24-hydroxy-24-ethylcholesta-5,28(29)-diene (24), tiglic acid 1-O-β-d-glucopyranoside (35), and 6,9-dihydroxymegastigmasta-5,7-dien-3-one 9-O-β-d-gentiobioside (46), have been isolated and elucidated for the first time. All of the compounds were tested for their radical-scavenging and antioxidant activities by measuring their capacity to scavenge the 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical, and anion superoxide radical and to induce the reduction of Mo(VI) to Mo(V). The antiproliferative activity of all the most abundant compounds by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) bioassay on murine B16-F1 melanoma cells has been also assessed. © 2009 Elsevier Ltd. All rights reserved.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11591/186703
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