Some considerations about the composition, in vivo detection and therapeutic approaches to the coronary atherosclerotic plaques in diabetes mellitus

vascular disease with hyperglicemia as a late manifestation [1]. It’s known that T2DM causes coronary morbility and mortality from two to six times more than in individuals without diabetes [2]. Mortality from stroke rised almost 3-fold when diabetics are matched to the persons without diabetes [3]. Peripheral arterial and retinal diseases are some common complications of diabetes mellitus [4]. Patients having diabetes have an enhanced myocardial dysfunction, often evolving in chronic heart failure [5–7]. Premature atherosclerosis, hyperglycemia, increased insulin resistance and glycosilation of some proteins are undelay all these cardiovascular occurrences. In addition, these impairments often are clouped with elevated blood pressure and hyperhomocisteine, obesity, rised levels of triglycerides and low HDL-cholesterol. These conditions further favour the atherosclerotic processes